Endocrine Disruptors

At MDS we offer models and high throughput assays to determine which chemicals have endocrine disrupting activity. A selected list of these assays are as follows. Please click on the assay name for further details.

Assay Name	In Vitro		In Vivo
	Rat	Human	Rat	Fish	Amphibian
ER binding (Rat uterine cytosol estrogen receptor binding)	X
ER binding (Human recombinant estrogen receptor binding)		X
AR binding (Rat prostate cytosol androgen receptor binding)	X
Human cell line (H295R) steroidogenesis (two parts of protocol- part 1 is cell culture, part 2 is exposure)		X
Human placental & recombinant aromatase (one assay using either human placental or recombinant microsomes))		X
Uterotrophic (rat)			X
Hershberger (rat)			X
Pubertal female (rat)			X
Pubertal male (rat)			X
Amphibian metamorphosis (frog)					X
Fish Short-term reproduction (fish) (two parts of protocol- 2nd part is AppE histopath guidelines)				X