Estrogen Receptor (ER) Binding Assays Using the CERI Human Recombinant ER&alpha

The Estrogen Receptor (ER) Binding Assay serves as an in vitro screening assay for identifying compounds that can bind to the recombinant human estrogen receptor-α. It is used to determine the ability of a compound to compete with 17β-estradiol for binding to the recombinant human estrogen receptor-α (hrERα)-ligand binding domain (LBD)

This assay is part of the OECD framework for the Testing and Assessment of Endocrine Disrupting Chemicals” under the EPA.