Uterotrophic Bioassay

The Uterotropic Bioassay serves as an in vivo screening assay to evaluate the ability of a chemical to elicit biological activities consistent with agonists or antagonists of natural oestrogens. This assay is part of the OECD framework for the Testing and Assessment of Endocrine Disrupting Chemicals” under the EPA. Uterine weight, in immature or ovariectomy female rats, will be evaluated following administration of your chemical of choice. The assay employs both strong and weak estrogen agonists to evaluate the performance of the assay, and to identify estrogenic compounds.