Syngeneic Transplants In Rats And Mice

Murine Tumor Models

• Syngeneic cancer cell lines generate tumors in mice with an intact immune system
• Serves as a model of metastatic disease

Examples of syngeneic cell lines

• Mouse leukemia (L1210, P-388)
• Mouse melanoma (B-16)
• Rat glio sarcoma (9L)
• Rat adeno carcinoma (R-230)

Based in part on the growth rate, primary tumor formation, metastatic rate, and tumor pathology, we can determine whether the cell line is suitable for use in a xenograft or syngeneic model.