Carcinogen-Induced Models:

• Carcinogen-induced animal models include the DMBA and NMU mammary tumor models in rats
• 65-85% incidence of mammary tumors in rats
• Average of 3-5 tumors per animal
• Wide spectrum of benign and highly malignant tumor types

Evaluating Drug Effects on Radiation Efficacy and Toxicity

Metastasis Models

• Spontaneous metastasis
  • Orthotopic and footpad implantation
  • Intravenous injection

Angiogenesis Models

• Z-chamber
• Dorsal skin flap window chamber