In Vitro Pluripotency Assays
MDS Scientist will design and perform specific protocols for identification of genes and cell surface markers for somatic stem cells or lineage precursors to investigate molecular and cellular processes involved in lineage-specification and embryogenesis.
MDS also offers testing for evaluation of the effects of any potential drug candidate, or herbal substance that can affect the hematopoietic system even if it is not an agent directed toward hematopoiesis.
Other services include:
- Growth and maintenance of germline ES cells for the generation of chimeric and transgenic mice
- Growth and maintenance of undifferentiated ES cells for in vitro differentiation to hematopoietic, pancreatic, endothelial and neural lineages
- Analysis of gene expression patterns during embryonic development and differentiation
- Provides ideal model systems for the generation of specific cell types for potential therapeutic approaches
- Creation of genetically modified ES cells (knockout, transgenic, antisense) for functional studies
- Evaluation of the effects of external stimuli on developmental processes
- Identification of novel developmentally regulated genes using gene trap, degenerate PCR, or RNA subtraction techniques