Assay Design and Development

MDS offers a wide range of assay design and development services. Functional assays are designed, validated and customized to the needs of our pharmaceutical and biotechnology industry clients. These assays are aimed at assessing and monitoring the efficacy, tolerability and safety parameters of candidate therapeutics and prophylactics in cancer, infectious disease, autoimmunity and transplantation. Assays are derived from pertinent scientific literature or are directly implemented from already developed procedures.

• DNA Replication
• Apoptosis
• Na/K ATPase Activity
• Ca ATPase Activity
• Histone Acetylase / Deacetylase
• Regulation of Nuclear Receptor Binding by LFFA (long chain free fatty acids) and CoALFFA (CoA derivatives of free fatty acids)
• Caloric Restriction Mimetics

Custom Screening Services: MDS offers on-demand high-throughput screening and pharmacology profiling assays with multiple methodologies.

Assay Options:

• Full custom assay development based on a target of your choice
• Optimization of your assay protocol for high throughput screening
• High throughput screening/profiling with significant economies of scale for large compound numbers
• Rapid, testing of lead compound analogue libraries or screening hits for multi-parametric activity profiles (primary assay potency, in vitro ADMET, selectivity)
• Multiple assay platforms/detection methods
• Custom data formatting

Assay Categories: Our pharmacology profiling assay categories include:

• Enzymes
• Binding
• Cellular
• Tissue
• Animal
• Microbial
• Tumor

For in vitro ADME studies, please click the following link: In Vitro ADME