Molecular Diagnostics Services, Inc.
A Contract Research Organization

SNP Genotyping

Single nucleotide polymorphisms (SNPs) are the most common form of mutation in the genome. MDS can identify candidate SNPs in mRNA transcription regions (cSNPs) or in nearby genomic regions by sequencing. For genes specifically associated with traits of interest, the SNP targeted may be the cause of the variant trait.

Individual SNP Profiling:

SNP profiling services are offered for pharmacokinetic, pharmacodynamic, safety, tolerability, and efficiency outcomes through genotype/phenotype correlation analysis. To support these SNP profiling applications, MDS offers PCR/gel-based analysis (i.e. RFLP assays) and other genotyping services for a number of drug metabolism enzymes and other clinically relevant genes:

  • 5HHT
  • Alpha 2
    Macroglobulin (A2M)
  • APOE
  • COMT
  • CYP2A6
  • CYP2C19
  • CYP2C9
  • CYP2D6
  • CYP3A4
  • CYP3A5
  • DRD2
  • F2
  • Factor V Leiden
  • FLT3
  • MDR1
  • NAT2
  • PPAR
    (alpha, gamma, gamma2)
  • SDC4
  • UGT1A1

Custom assay design of customer specified SNPs can be performed from either text based sequence files containing the polymorphism and surrounding sequence or from SNP accession number information.

We will design oligonucleotide sequences for PCR amplification of the genomic region surrounding the SNP locus and the detection oligonucleotide that hybridizes adjacent to the SNP locus.

Pre-Production Optimization

Before genotyping is scaled up for a particular SNP, several optimization and standardization reactions need to be performed. These include: Primer Design
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©2007 Molecular Diagnostic Services, Inc.