Molecular Diagnostics Services, Inc.
A Contract Research Organization

Drug Metabolism and Pharmacokinetics (DMPK)

MDS’s expert in PK/PD modeling and simulation will assist our clients for conducting complex and advanced PK/PD experiments for discovery, pharmacology, and toxicology, and compound development strategy.  

Our services include designing screening experiments to characterize the determinants of in vivo exposure and to integrate this information with in vitro data in order to build a full pharmacokinetic understanding for the suitability of molecules to progress to man

In a typical PK study, blood samples are obtained from test animals following a single dose or a timed perfusion of the test compound(s). Plasma samples are collected, separated and analyzed. Typically, if the drug is going to be administered orally, both an i.v. PK and an oral PK should be run simultaneously, so that the pharmacokinetics of the drug can be calculated. The data is also used to generate concentration vs. time curves and allows the determination of fundamental PK parameters such as Cmax, Tmax, AUC, drug clearance, terminal elimination half-life , oral bioavailability and volume of distribution.

MDS offers extensive capabilities to conduct in vivo pharmacokinetic evaluations and analyses. These studies provide information for selection of dose levels, dosing frequency, formulation, routes of administration, exposure and interspecies comparison.   We have biostatisticians and pharmacokineticists on staff, applying the latest techniques and software to evaluate the data.

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©2007 Molecular Diagnostic Services, Inc.