Molecular Diagnostics Services, Inc.
A Contract Research Organization


To support companies and academic laboratories in the development of angiogenic or inhibitory compounds, MDS offers an integrated series of in vitro and in vivo angiogenesis assays.

Angiogenesis is important in normal biological processes such as development and wound healing. In adults, angiogenesis is generally a response to increased tissue mass, alterations in oxygen tension or both. This change in tissue mass or oxygen tension can be the result of a tumor. Angiogenesis plays a key role in tumor growth and development since blood vessels are required to maintain oxygen homeostasis, deliver nutrients and remove waste products.

In Vitro Assays Chemotaxis / Cell Migration

Human vascular endothelial cell culture (HUVEC) populations are very responsive to compounds that modulate angiogenic response. Pro-angiogenic compounds promote increased growth and differentiation rates in these cells. Activated endothelial cells become highly chemotactic. We can evaluate the effect of compounds on the growth rate of HUVEC cells and, by using Boyden chambers, a compound's ability to induce migration through a defined matrix.

Angiogenesis (In Vivo): Tumor Models
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