Cancer Stem Cells:

Ankrd26
POTE gene is expressed in prostate and breast cancer and a potential candidate for immuno-therapy. It is also expressed in undifferentiated embryonic stem cells. Ankrd26 is the ancestral gene of POTE and has a homologue in mouse. Mouse Ankrd26 is also selectively expressed in embryonic stem cells and various cancers but not in other adult tissues. The encoded protein of Ankrd26 contains ankyrin repeats and coiled coil domain of spectrin suggestive of a signaling molecule. Alternative names:

• Ankyrin repeat domain 26 or
• bA145E8.1
• KIAA1074

PAR6
Par6 is a cell membrane protein involved in cell polarization and asymmetrical cell division processes as part of a multi-protein complex. It is thought to be involved in the invasive phenotype that is associated with metastatic carcinomas, playing a role in the epithelial to mesenchymal transition (EMT). Par6 is also thought to be involved in the formation of epithelial tight junctions. Par6 contains a semi Cdc42/Rac interactive binding (CRIB) domain and a PDZ (PSD95/Discs-large/ZO1) domain, and several different Par6 isoforms have been identified. Alternative names for PAR6

• Tax interacting protein 40
• TAX40
• TIP 40