Biodistribution & Bioavailability Studies

The measurement of the biodistribution of radiopharmaceuticals and DNA-based therapeutics is an important aspect in calculating absorbed dose from internally deposited radionuclides by either imaging or non-imaging measurement techniques. These include the following:

• Mass balance measurements
• Blood and plasma kinetics
• Quantitative tissue distribution (single and repeated administration)
• Biliary excretion
• Enterohepatic recirculation
• Protein binding
• Excreta counting

Data processing involves curve-fitting techniques to integrate the source time-activity curves (determining the area under these curves) and to evaluate plasma protein binding vs. distribution to extracellular fluid. Routes of administration include oral, intravenous, topical, intraperitoneal, inhalation, intrathecal, and infusion as well as other intended delivery methods for your compound.